The Computational Biology Review

Dispatch

Writing on genomics, methods, and precision medicine

Est. 2023 · 3 dispatches

Ananya G. Bhaya

GENOMICS

Why Single-Cell Sequencing Is Transforming Precision Medicine

12 Mar 20246 min readVol. IV

Bulk RNA-seq averages out the richness of cellular diversity. Here's why resolving individual cell states changes everything for drug targeting and disease stratification.

scRNA-seqPrecision Medicine

POPULATION GENETICS

The Ancestral Bias Problem in Polygenic Risk Scores

Most GWAS cohorts are >80% European. This creates PRS models that generalise poorly across ancestries — and may worsen health disparities. What can we do about it?

4 Nov 20238 min read

METHODS

A Practical Guide to Multi-Omics Data Integration

From simple concatenation to graph neural networks — a walkthrough of common multi-omics integration strategies, with notes on when each approach actually works.

19 Aug 202310 min read

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