Research

3 publications

Peer-reviewed work in computational biology, precision medicine, and machine learning.

FeaturedAtlasNature Communications · 2024

Single-cell transcriptomic atlas of tumor microenvironments in pancreatic cancer

120k cells · 40 biopsies

Key metric

We present a single-cell RNA-seq atlas of 120,000 cells from 40 pancreatic tumor biopsies, revealing novel immunosuppressive myeloid subtypes associated with poor prognosis.

Bhaya A, Chen R, Liu Y, et al.
42citations
scRNA-seqTumor MicroenvironmentPancreatic Cancer
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Multimodal ML

Machine learning integration of EHR and genomic data for sepsis outcome prediction

npj Digital Medicine · 2023

A multimodal deep learning model integrating whole-genome sequencing features with clinical time-series data achieves AUROC 0.89 in predicting 30-day sepsis mortality.

EHRGenomicsDeep LearningSepsis
18cit.
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Population Genetics

Polygenic risk score calibration across diverse ancestries using transfer learning

The American Journal of Human Genetics · 2023

We demonstrate that transfer learning from large European GWAS can substantially improve PRS accuracy in underrepresented populations with minimal additional data.

PRSGWASAncestryTransfer Learning
31cit.
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